office location:Li Hua Lou Room 111, Xue Yuan Lu #30, Beijng 100083, China
Research Interests:1.Nuclear receptor LXR signaling and application.

2.Synthetic biology (PI for iGEM)

Cholesterol metabolism is essential in human physiology and common metabolic diseases. We have been working on cholesterol
pathology for 30 years, starting from cloning the cholesterol sensor nuclear receptor LXR. It has been increasingly evident
that modulation of LXR activity is effective to deccelerate cholesterol accumulation in vascular systems and neurological tissues
and slow down the pathological progression of vascular diseases to prevent heart attack and stroke. Diabetes and Alzheimer's disease
may also be therapeutically targeted by LXR signaling pathway.
In addition to dissect out molecular detail of LXR signaling pathway, synthetic biology method is applied to generate an
accelerated aging process where mitochondria is producing ROS is situ under command. A light-powered proton pump is constructed
in the inner membrane of mitochondira of cultured human cells. This platform will provide new insight of oxidation hypothesis of

2005-present professor, USTB

1998-2005 Research Associate University of Chicago US
1994-1996 Senior Scientist, Glaxo Research Institute, US
1989-1994 Ph.D candicate in Bicheistry and Molecular Biology, University of Chicago, US
1984-1988 Undergradaute student in Biology Department, Peking University

Scientific research achievements


Enrollment plan


Representative papers


Postgraduate training


  • School of Chemistry and Biological Engineering, USTB
  • 30 Xueyuan Road, Haidian District, Beijing,100083