DU Hongwu

office location:--
Research Interests:As n an t independent pl rincipal , investigator, y my h research t interest s was y mainly d focused on
l mesenchymal m stem l cell y therapy r for e some autoimmune e , diseases, e rare s diseases d and age-related
e neurodegenerative disorders. . , Also, e we e are g trying o to d find s biomarkers r for h such s diseases with
s systems y biology . technology. o So r far e we e have d found t about 0 50 w new s antigens r for autoimmune
diseases s, , 6 6 w new c specific s auto-antigens r for Behcet’ ’s s . disease. e We e hope o to d build a a connection
n between e the s biomarkers d and e the eff icac cy y f of m stem l cell , therapy, d and e elucidate e the pathogenesis
f of e those diseases.

2001.9– – 2005.1: . Ph.D. n in Biotechnology, School of Medicine, a Tsinghua University , Beijing 100084, P. R. China. Dissertation Supervisor: Cheung Kong Prof. Jing Cheng (jcheng@tsing-hua.edu.cn)
1997.8– – 2000.7: . M.S. n in r Molecular Immunology, , Department of etiology, Institute of Basic Medical Sciences, e Chinese y Academy f of l Medical s Sciences d and g Peking Union PROFESSIONAL EXPERIENCE
2015.8-present: Professor, School of Chemistry & Biotechnology Engineering, University of Science & Technology Beijing (Rare Disease Research)
20 10.7- - 2011.8: : f Staff Scientist, , n Human e Immune r Monitor , Center, d Stanford y University School f of , medicine, , Stanford, , CA, USA.
2009.6- 2010.6: : g Visiting h Research , Associate, t Department f of , medicine, d Stanford University l School f of , medicine, , Stanford, , CA, USA.
2007.1– – 20 15. .7 7: : e Associate , Professor, y Deputy Director, Department of Biology, School of Applied Science, y University f of e Science d and y Technology Beijing . Beijing, China.( http://www.ustb.edu.cn )
2000.10– –: 2005.9: r Senior , Scientist, Director, , Department of Proteomics and immunology, National Engineering Research Center for Beijing Biochip Technology , Beijing, China. (http://www.capitalbio.com) l Medical College (CAMS&PUMC), Beijing 100005, P.R.China. Dissertation Supervisor: Prof. Heng Wang (hengwang@pumc.edu.cn)
1993.9– – 1997.7: . B.S. n in , Biotechnology, College of Life Science, Shandong University , Jinan, 250001, P.R.China Thesis research (1996.12-1997.6): State Key Laboratory of Reproductive, Institute of Zoology, , e Chinese y Academy f of Science

Scientific research achievements

1) Excellence in Research Award (2005, l National g Engineering h Research r Center r for Beijing p Biochip Technology , Beijing, China).
2) Beijing Noval Star of Science & Technology (2007, g Beijing City Council , Beijing, China).
3) The Honorable Title, the 29 th Beijing Hi-tech Olympics (2008, Chinese Ministry of Science and Technology , China).
4) Outstanding Contribution Award (2011, HIMC , USA)
5) New Century Excellent Talents (2013, e Chinese y Ministry f of Education , China)
6) Outstanding Innovation Achievement Award (2016, g Beijing y City Government, , Beijing,China)
7) Best Industrial Prospects Award (2016, g Beijing y City Government, , Beijing, China)

Enrollment plan


Representative papers

1) Jiao X, Zhou Y, Zhao D, Pang D, Wang C, Hongwu Du, Wen Y, Zhang X. An indirect ELISA-inspired dual-channel fluorescent immunoassay based on MPA-capped CdTe/ZnS QDs. Anal Bioanal Chem. 2019 Jul 13. doi: 10.1007/s00216-019-01917-9. [Epub ahead of print]
2) Zhou Y, Cui J, Hongwu Du. Autoantibody-targeted TAAs in pancreatic cancer: A comprehensive analysis. Pancreatology. 2019 Jun 19. pii: S1424-3903(19)30610-6. doi: 10.1016/j.pan.2019.06.009. [Epub ahead of print]
3) Zhu M, Zhang J, Zhou Y, Xing P, Gong L, Su C, Qi D, Hongwu Du , Bian Y, Jiang J. Two-Photon Excited FRET Dyads for Lysosome-Targeted Imaging and Photodynamic Therapy. Inorg Chem. 2018 Sep 17;57(18):11537-11542. doi: 10.1021/acs.inorgchem.8b01581. Epub 2018 Aug 29.
4) Hussain M, Xiao J, Zhang Y, Chen P, Hongwu Du. Identification of hnRNP C1/C2 as an Autoantigen in Patients with Behcet's Disease. Iran J Immunol. 2018 Jun;15(2):133-141. doi: IJIv15i2A6.
5) Zhang Y, Hussain M, Yang X, Chen P, Yang C, Xun Y, Tian Y, Hongwu Du. Identification of Moesin as a Novel Autoantigen in Patients with Sjögren's Syndrome. Protein Pept Lett. 2018;25(4):350-355. doi: 10.2174/0929866525666180320110135.
6) Hussain M, Chen P, Mei G, Li Y, Hongwu Du. Expression correlates between Annexin A1 and A2 autoantibodies in patients with Behçet's disease. Biosci Rep. 2018 Jan 19;38(1). pii: BSR20170778. doi: 10.1042/BSR20170778. Print 2018 Feb 28.
7) Meng X, Cui J, Wang Y, Zhang X, Li D, Hai Y, Hongwu Du. Heterogeneous nuclear ribonucleoprotein A1 interacts with microRNA-34a to promote chondrogenic differentiation of mesenchymal stem cells.Am J Transl Res. 2017 Apr 15;9(4):1774-1782. eCollection 2017.
8) Li Y, Hongwu Du, Wang W, Zhang P, Xu L, Wen Y, Zhang X. Corrigendum: A Versatile Multiple Target Detection System Based on DNA Nano-assembled Linear FRET Arrays. Sci Rep. 2016 Jul 7; 6:28411. doi: 10.1038/srep28411.
9) Peng Chen, Chunyan Zhang, Chen Liu, Liyun Zhang, Chunhe Yang, Guangyu Chen, Dan Ma, Yaping Tian, Hongwu Du. HnRNP A1 is Involved in Deep Vein Thrombosis Patients with Behçet's Disease. EBioMedicine. 2016 Mar 10. doi: 10.1016/j.ebiom.2016.03.009.
10) Chunhe Yang, Peng Chen, Wen Zhang, Hongwu Du. Bioinformatics driven new immune target discovery in disease. Scandinavian Journal of Immunology. 2016 May 26.doi: 10.111/sji.12452.
11) Peng Chen, Hai Yan, Wen Zhang, Chunhe Yang, Hongwu Du. Anti-LAMIN A/C antibodies in patients with Behçet disease. Central Europern Immunology. 2016, doi:10.2174/1573412911666150.
12) L Zhao, C Zhao, Z Du, Hongwu Du. Lactate Dehydrogenase is involved in but not the Target Antigen in Children with Kawasaki Disease. J Cardiovasc Med Cardiol. 2016 Feb 203 (1): 007.
13) Chunhe Yang, Hongwu Du. Evaluation by hierarchical clustering of multiple cytokine expression after phytohemagglutinin stimulation.Archives of Biological Sciences. 2016, 0.10161603.
14) Xiuqin Yang, Peng Chen, Hongwu Du. Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behçet’ s Disease. Journal of Clinical & Cellular Immunology.Accepted. (2016).
15) Li Y, Hongwu Du, Wang W, Zhang P, Xu L, Wen Y, Zhang X.A Versatile Multiple Target Detection System Based on DNA Nano-assembled Linear FRET Arrays.Sci Rep. 2016 May 27;6:26879. doi: 10.1038/srep26879.
16) Wang X, Chen P, Cui J, Yang C, Hongwu Du. Keratin 8 is a novel autoantigen of rheumatoid arthritis. Biochem Biophys Res Commun. 2015 Aug 12. pii: S0006-291X(15)30390-9. doi:10.1016/j.bbrc.2015.07.161.
17) Liang J, Yang W, Meng X, Chen P, Hongwu Du. Heterogeneous Nuclear Ribonucleoprotein A2/B1 as a Target Antigen in Han Chinese for BD Patients. Protein Pept Lett. 2015;22(6):504-8. PMID:259257704.
18) Whiting CC, Siebert J, Newman AM, Hongwu Du, Alizadeh AA, Goronzy J, Weyand CM, Krishnan E, Fathman CG,Maecker HT. Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging. PLoS One. 2015, 10(7):e0133627. doi: 10.1371/journal.pone.0133627.
19) Hongwu Du, Chen G, Bian Y, Xing C, Ding X, Zhu M, Xun Y, Chen P, Zhou Y, Li S. Screening hybridomas for anabolic androgenic steroids by steroid analog antigen microarray. Bioanalysis. 2015;7(10):1201-9. doi: 10.4155/bio.15.67. Epub 2015 May 14.PMID: 259739865.
20) Li Y, Wang W, Zhao D, Chen P, Hongwu Du, Wen Y, Zhang X. Water-Soluble Fluorescent CdTe/ZnSe Core/Shell Quantum Dot: Aqueous Phase Synthesis and Cytotoxicity Assays. J Nanosci Nanotechnol. 2015, 15(6):4648-52.
21) Yiping Xun, Hongwu Du. Combinatorial Application of Multiple High-throughput Biotechnologies for the Study ofAutoimmune Diseases. Current PharmaceuticalAnalysis 2015.05 SCIE doi:10.2174/15734129116661501212339167.
22) Lili Shi, Hongwu Du. Prohibitin as a novel autoantigen in rheumatoid arthritis. Centr Eur J Immunol 2015.04 SCIE doi: 10.5114/ceji.2015.508378.
23) Lili Shi, Yioping Xun, Jia Liu, Hongwu Du. Prohibitin Is Involved in Patients with IgG4 Related Disease. PLoS One.2015.05 SCIE doi: 10.1371/journal.pone.0125331. eCollection 20159.
24) Xu, Huimin; Wang, Huasheng; Xu, Qianqian, Hongwu Du, Hai Yan. Pathway for Biodegrading Microcystin-YR by Sphingopyxis sp. USTB-05. PloS one.2015, 10:4,e0124425.
25) Yiping Xun, Hai Yan, Jia Liu, Lili Shi, Peng Chen, Hongwu Du. Development of a high-throughput Immunoassay for rapid detection of multiple antibiotic residues in cosmetics. Advanced Materials Research. 2014,1073-1076:357-361.
26) Peng Chen, Jia Liu, Lili Shi, Guangyu Chen, Hongwu Du. Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial CellAutoantigen in Behçet's Disease. PLoS One. 2015.04 doi: 10.1371/ journal.pone.0124760. eCollection 201512.
27) Chen P, Yan H, Tian Y, Xun Y, Shi L, Bao R, Zhang H, Chen G, Yang C, Sun S, Wang Y, Liu L, Zhou Y, Zhang C, Wang X, Wen Y, Bian Y, Hongwu Du. Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease. Sci Rep. 2015 Feb 2;5:8162. doi: 10.1038/srep08162.PMID: 25641213.
28) Xun Y, Chen G, Wang X, Chen W, Hongwu Du. Identification of heat shock protein 27 as a novel autoantigen of Behçet's disease. Biochem Biophys Res Commun. 2015 Jan 18. pii: 0006-291X(14)02246-3. doi: 10.1016/j.bbrc.2015.1.064. 4. 141.
29) M. Zhu, Y. Zhou, L. Yang, L. Li, D. Qi, M. Bai, Y. Chen, Hongwu Du. Synergistic Coupling of Fluorescent "Turn-Off" with Spectral Overlap Modulated FRET for Ratiometric Ag(+) Sensor, Inorg Chem 53 (2014) 12186-12190.
30) Hongwu Du, G.Y. Chen, C.H. Yang, C.B. Li, Y.P. Xun, J. Liu, P. Chen, L.L. Shi, Multiple correlations of mRNA expression and protein abundance in human cytokine profile, Mol Biol Rep 41 (2014) 6985-6993.
31) Hongwu Du, Chen G, Bian Y, Xing C, Ding X, Zhu M, Xun Y, Chen P, Zhou Y, Li S1. Screening hybridomas for anabolic androgenic steroids by steroid analog antigen microarray. Bioanalysis. 2015 May 14;7(10):1201-9. doi: 10.4155/bio.15.67.
32) W. Wang, L. Chen, L.P. Xu, Hongwu Du, Y. Wen, Y. Song, X. Zhang. A Free-Blockage Controlled Release System Based on the Hydrophobic/Hydrophilic Conversion of Mesoporous Silica Nanopores, Chemistry. 2015, 21(6):2680-5. .
33) P. Chen, L. Shi, Y. Jiang, Y. Ji, H. Yan, S. Sun, Y. Xun, G. Chen, X. Wang, W. Chen, Hongwu Du. Identification of heat shock protein 27 as a novel autoantigen of Behcet's disease, Biochem Biophys Res Commun 2014, 12, 064
34)Lili Shi, G. Chen, Hongwu Du. Identification of prohibitin as an antigen in Behcet's disease, Biochem Biophys Res Commun 2014, 451(3):389-93.
35) Hongwu Du, J. Liu, Y. Xun, J. Liang, S. Li, G. Chen, Determination of Deoxynivalenol, Zearalenone, Aflatoxin B1, and Ochratoxin by an Enzyme-Linked ImmunosorbentAssay,Anal Lett (2014)
36) W. Wang, Y. Wen, L. Xu, , Hongwu Du, Y. Zhou, X. Zhang. A selective release system based on dual-drug-loaded mesoporous silica for nanoparticle-assisted combination therapy, Chemistry 2014, 7796-7802.
37) Y. Zhao, X. Yan, Z. Kang, X. Fang, X. Zheng, L. Zhao, Hongwu Du, Y. Zhang, Zinc oxide nanowires-based electrochemical biosensor for L-lactic acid amperometric detection, Journal of Nanoparticle Research 16 (2014) 1-9.
38) L. Sun, J. Lin, Hongwu Du, C. Hu, Z. Huang, Z. Lv, C. Zheng, X. Shi, Y. Zhang, Z. Yang, Gender-specific DNA methylome analysis of a han chinese longevity population, Biomed Res Int 2014 ,396727.
39)L.L. Ritterhouse, R. Lu, H.B. Shah, J.M. Robertson, D.A. Fife, H.T. Maecker, Hongwu Du, C.G. Fathman, E.F. Chakravarty, R.H. Scofield, D.L. Kamen, J.M. Guthridge, J.A. James, Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin d deficient European-american healthy controls, PLoS One 2014, 9 e94500.
40) Zhuo Kang, Xiaoqin Yan, Lanqing Zhao, Qingliang Liao, Yi Liu, Zheng Zhang, Kun Zhao, Hongwu Du, Pei Lin, Zhiming Bai, Yue Zhang. Gold nanoparticles/ZnO nanorods hybrids for enhanced reactive oxygen species generation and photodynamic therapy. Nono Research. 2014, 33:186-198.
41) Sun L, Lin J, Hongwu Du, Hu C, Huang Z, Lv Z4, Zheng C, Shi X, Zhang Y, Yang Z. Gender-specific DNA Methylome Analysis of a Han Chinese Longevity Population. Biomed Res Int. 2014:396727.
42) L. Chen, W. Wang, B. Su, Y. Wen, C. Li, Y. Zhou, M. Li, X. Shi, Hongwu Du, Y. Song, L. Jiang, A light-responsive release platform by controlling the wetting behavior of hydrophobic surface, ACS Nano 2014, 8:744-751.
43)Enzyme-coated single ZnO nanowire FET biosensor for detection of uric acid. Sensors & Actuators B Chemical. 2013, 176(6): 22-27
44) Xu LP, Liu Y, Zhao J, Wang S, Lin CS, Zhang RQ, Wen Y, Hongwu Du, Zhang X. Self-assembly of thiophene derivatives on highly oriented pyrolytic graphite: hydrogen bond effect. J Nanosci Nanotechnol. 2013, Feb;13(2):1226-31.
45) Wang S1, Xu LP, Wen Y, Hongwu Du, Wang S, Zhang X. Space-confined fabrication of silver nanodendrites and their enhanced SERS activity. Nanoscale. 2013, 5(10):4284-90.
46) Hongwu Du, Chuanbao Li, Haimin Jin, Guangyu Chen, Yiping Xun. Generation and evaluation of antibodies against human MGF E-peptide by reverse phase protein microarray and reverse competitive ELISA. Bioanalysis. 2013, 5(18):2269-75.
47) Yongqiang Wen, Wang W, Zhang Z, Xu L, Hongwu Du, Zhang X, Song Y. Controllable and reproducible construction of a SERS substrate and its sensing applications. Nanoscale. 2013, 5(2):523-6.
48) Wen Y, Xu L, Li C, Hongwu Du, Chen L, Su B, Zhang Z, Zhang X, Song Y. DNA-based intelligent logic controlled release systems. Chem Commun (Camb). 2012, 48(67): 8410-2
49) Hongwu Du, Chen G, Wang S, Wang S, Li S, Li C, Xun Y, He C, Wu M. Immunological screening and characterization of highly specific monoclonal antibodies against 20 kDa hGH. Bioanalysis. 2012,4(17): 2161-8.
50) Dong H, Zhang J, Ju H, Lu H, Wang S, Jin S, Hao K, Hongwu Du, Zhang X. Highly sensitive multiple microRNA detection based on fluorescence quenching of graphene oxide and isothermal strand-displacement polymerase reaction.Anal Chem. 2012, 84: 4587-93.
51) Wen Y1, Xu L, Wang W, Wang D, Hongwu Du, Zhang X. Highly efficient remote controlled release system based on light-driven DNA nanomachine functionalized mesoporous silica. Nanoscale. 2012, 4(15):4473-6.
52)Wen Y1, Chen L, Wang W, Xu L, Hongwu Du, Zhang Z, Zhang X, Song Y. A flexible DNA modification approach towards construction of gold nanoparticle assemblies. Chem Commun (Camb). 2012, 48(33):3963-5.
53) Wang S., Wei Y., Chen G., Liu X., Jin H., Yan Z., Wu Q., Hongwu Du. Generation and utilization of anti-drug monoclonal antibodies for screening of 36 drug users by dot-ELISA. Hybridoma (Larchmt). 2009Apr;28(2):145-8. doi: 10.1089/hyb.2008.0078.
54)Such-Sanmartín G., Bosch J., Segura J., Wu M., Hongwu Du, Chen G., Wang S., Vila-Perelló M., Andreu D., Gutiérrez-Gallego R. Characterisation of the 5 kDa growth hormone isoform. Growth Factors. 2008, 26: 152-162.
55) Chen G., Hongwu Du, Peng S., Xu D., Wang J. Construction and direct immunization of eukaryotic expression plasmid encoding human soluble B lymphocyte stimulator. Front Biosci. 2006, 11:121-125.
56) Chen G., Hongwu Du, Xu D., Peng S., Wang J. Development of an immunoassay kit for detecting the alteration of serum B cell activating factor in thermally injured mice. Mol Cell Biochem. 2006, 281:185-188.
57) Hongwu Du, Cheng J. Protein chips for high-throughput drug screening in athletes. Expert Rev Proteomics. 2006, 3;111-114. (Review)
58) Hongwu Du, Yang W., Xing W., Su Y., Cheng J. Parallel Detection and Quantitation of Nine Immunoaaays Using a Protein Microarray in Serum. Biomed Microdevices. 2005, 7: 143-146.
59) Chen G., Hongwu Du, Zhang Z., Peng S., Xu D., Wang J. Primary immune effects of eukaryotic expression plasmids encoding two hyperactive mutants of human soluble B lymphocyte stimulator. J Clin Immunol. 2005, 25: 445-451.
60) Hongwu Du, Wu M., Yang W., Yuan G., Sun Y., Lu Y., Zhao S., Du Q., Wang J., Yang S., Pan M., Lu Y., Wang S., Cheng J. Development of miniaturized competitive immunoassays on a protein chip as a screening tool for drugs. Clin Chem. 2005, 51: 368-375.
61) Hongwu Du., Lu Y., Yang W., Wu M., Wang J., Zhao S., Pan M., Cheng J. Preparation of Steroid Antibodies and Parallel Detection of Multianabolic Steroid Abuse with Conjugated Hapten Microarray.Anal Chem. 2004, 76: 6166-6171.

Postgraduate training


  • School of Chemistry and Biological Engineering, USTB
  • 30 Xueyuan Road, Haidian District, Beijing,100083